Encefalopatía hepática mínima

Autores/as

  • Crhistian Gómez
  • Juan Carlos Restrepo

DOI:

https://doi.org/10.22516/25007440.84

Palabras clave:

Encefalopatía, encefalopatía hepática mínima, cirrosis hepática

Resumen

La encefalopatía hepática mínima (EHM) es un síndrome neurocognitivo, potencialmente reversible, constituido por una serie de alteraciones neuropsicológicas en pacientes con hepatopatía aguda o crónica, sin evidencia de anormalidades neurológicas durante la exploración física. La EHM es responsable del déficit cognitivo y tiene un impacto negativo sobre la calidad de vida de los pacientes, esencialmente con diagnóstico de cirrosis. La imposibilidad para detectar de manera clínica las alteraciones neuropsicológicas, alienta al clínico para la utilización de pruebas psicométricas, las cuales constituyen la base del cribado y el diagnóstico. La EHM modifica el pronóstico de la enfermedad. La detección oportuna permite intervenir el riesgo de desarrollar encefalopatía hepática clínica (EH) en los pacientes con cirrosis, lo cual se ha relacionado con una menor supervivencia. 

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Lenguajes:

es

Biografía del autor/a

Crhistian Gómez

Estudiante de Medicina de la Universidad de Antioquia. Medellín, Colombia. 

Juan Carlos Restrepo

Unidad de Hepatología y Programa de Trasplante de hígado, Hospital Pablo Tobón Uribe. Profesor titular, Facultad de Medicina de la Universidad de Antioquia. Jefe sección de Gastrohepatología, Jefe de posgrado de hepatología clínica. Universidad de Antioquia. Medellín, Colombia. 

Referencias bibliográficas

Stinton L, Jayakumar S. Minimal hepatic encephalopathy. Can J Gastroenterol. 2013;27:572-74.

Dhiman R. Impact of minimal/covert hepatic encephalopathy on patients with cirrhosis.Clin Liver Dis. 2015;5:75-8.

Lauridsen M, Vilstrup H. Diagnosing covert hepatic encephalopathy.Clin Liver Dis. 2015;5:71-4.

Allampati S, Mullen K. Nomenclature and definition of hepatic encephalopathy—An update. Clin Liver Dis. 2015;5:68-70.

Vilstrup H, Amodio P, Bajaj J, Córdoba J, Ferenci P, Mullen K, et al. Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver. Hepatology. 2014;60:715-35.

Prakash R, Kanna S, Mullen K. Evolving concepts: the negative effect of minimal hepatic encephalopathy and role for prophylaxis in patients with cirrhosis. ClinTher. 2013;35:1458-73.

Sharma P, Sharma B. A survey of patterns of practice and perception of minimal hepatic encephalopathy: A nationwide survey in India.Saudi J Gastroenterol. 2014;20:304-8.

Wang J, Zhang N, Chi B, Mi Y, Meng L, Liu Y, et al. Prevalence of minimal hepatic encephalopathy and quality of life evaluations in hospitalized cirrhotic patients in China. World J Gastroenterol. 2013;19:4984-91.

Tranah T, Paolino A, Shawcross D. Pathophysiological mechanisms of hepatic encephalopathy. Clin Liver Dis. 2015;5:59-63.

Cichoż-Lach H, Michalak A. Current pathogenetic aspects of hepatic encephalopathy and noncirrhotichyperammonemic encephalopathy. World J Gastroenterol. 2013;19:26-34.

Schomerus H, Hamster W. Neuropsychological aspects of portal-systemic encephalopathy. Metab Brain Dis. 1998;13:361-77.

Bémeur C, Butterworth R. Liver-brain proinflammatorysignalling in acute liver failure: role in the pathogenesis of hepatic encephalopathy and brain edema. Metab Brain Dis. 2013;28:145-50.

Moscucci F, Nardelli S, Pentassuglio L, Pasquale C, Ridola L, Merli M, et al. Previous overt hepatic encephalopathy rather than minimal hepatic encephalopathy impairs health‐related quality of life in cirrhotic patients. Liver Int. 2011;31:1505-10.

Bajaj J, Wade J, Gibson D, Heuman D, Thacker L, Sterling R, et al. The multi-dimensional burden of cirrhosis and hepatic encephalopathy on patients and caregivers. Am J Gastroenterol. 2011;106:1646-53.

Groeneweg M, Quero J, Bruijn I, Hartmann I, Essink-bot M, Hop W, et al. Subclinical hepatic encephalopathy impairs daily functioning. Hepatology. 1998;28:45-9.

Prasad S, Dhiman R, Duseja A, Chawla Y, Sharma A, Agarwal R. Lactulose improves cognitive functions and health‐related quality of life in patients with cirrhosis who have minimal hepatic encephalopathy. Hepatology. 2007;45:549-59.

Córdoba J, Cabrera J, Lataif L, Penev P, Zee P, Blei A. High prevalence of sleep disturbance in cirrhosis. Hepatology. 1998;27:339-45.

Steindl P, Finn B, Bendok B, Rothke S, Zee P, Blei A.Disruption of the diurnal rhythm of plasma melatonin in cirrhosis. Ann Intern Med. 1995;123:274-7.

Bajaj J, Saeian K, Schubert C, Hafeezullah M, Franco J, Varma R, et al. Minimal hepatic encephalopathy is associated with motor vehicle crashes: the reality beyond the driving test. Hepatology. 2009;50:1175-83.

Bajaj J, Pinkerton S, Sanyal A, Heuman D. Diagnosis and treatment of minimal hepatic encephalopathy to prevent motor vehicle accidents: A cost‐effectiveness analysis. Hepatology. 2012;55:1164-71.

Román E, Córdoba J, Torrens M, Torras X, Villanueva C, Vargas V, et al. Minimal hepatic encephalopathy is associated with falls. Am J Gastroenterol. 2011;106:476-82.

Hartmann I, Groeneweg M, Quero J, Beijeman S, Man R, Hop W, et al. The prognostic significance of subclinical hepatic encephalopathy. Am J Gastroenterol. 2000;95:2029-34.

Patidar K, Thacker L, Wade J, Sterling R, Sanyal A, Siddiqui M, et al. Covert Hepatic Encephalopathy Is Independently Associated With Poor Survival and Increased Risk of Hospitalization. Am J Gastroenterol. 2014;109:1757-63.

Irimia R, Stanciu C, Cojocariu C, Sfarti C, Trifan A. Oral glutamine challenge improves the performance of psychometric tests for the diagnosis of minimal hepatic encephalopathy in patients with liver cirrhosis. J Gastrointestin Liver Dis. 2013;22:277-81.

Lauridsen M, Thiele M, Kimer M, Vilstrup H.The continuousreaction times method for diagnosing, grading, and monitoring minimal/covert hepatic encephalopathy. MetabBrain Dis. 2013;28:231-34.

Bajaj J, Thacker L, Heuman D, Fuchs M, Sterling R, Sanyal A, et al. The Stroop smartphone application is a short and valid method to screen for minimal hepatic encephalopathy. Hepatology. 2013;58:1122-32.

Bajaj JS, Heuman DM, Sterling RK, Sanyal AJ, Siddiqui M, Matherly S, et al. Validation of EncephalApp, Smartphone-Based Stroop Test, for the Diagnosis of Covert Hepatic Encephalopathy. Clin Gastroenterol Hepatol.

;13(10):1828-1835.e1.

Torlot F, McPhail M, Taylor-Robinson S. Meta‐analysis: the diagnostic accuracy of critical flicker frequency in minimal hepatic encephalopathy. Aliment PharmacolTher. 2013;37:527-36.

Scheau C, Badarau A, Ghergus A, Popa G, Lupescu I. Minimal Hepatic Encephalopathy Diagnosis by Magnetic Resonance Spectroscopy. A Case Report. J Gastrointestin Liver Dis. 2013;22:455-9.

Dhiman R, Kurmi R, Thumburu K, Venkataramarao S, Agarwal R, Duseja A, et al. Diagnosis and prognostic significance of minimal hepatic encephalopathy in patients with cirrhosis of liver. Dig Dis Sci. 2010;55:2381-90.

Goldbecker A, Weissenborn K, Shahrezaei G, Afshar K,

Rumke S, Barg-Hock H, et al. Comparison of the most favoured methods for the diagnosis of hepatic encephalopathy in

liver transplantation candidates. Gut. 2013;62:1497-504.

Riggio O, Nardelli S, Gioia S, Lucidi C, Merli M. Management of hepatic encephalopathy as an inpatient. Clin Liver Dis. 2015;5:79-82.

Alfawaz H, Aljumah A. What improves minimal hepatic encephalopathy: Probiotic yogurt, protein restriction ornonabsorbable disaccharides? Saudi J Gastroenterol. 2012;18:153-4.

Sharma K, Pant S, Misra S, Dwivedi M, Misra A, Narang S, et al. Effect of rifaximin, probiotics, and l-ornithine l-aspartate on minimal hepatic encephalopathy: A randomized controlled trial. Saudi J Gastroenterol. 2014;20:225-32.

Córdoba J, López-Hellín J, Planas M, Sabín P, Sanpedro F, Castro F, et al.Normal protein diet for episodic hepatic encephalopathy: results of a randomized study. J Hepatol. 2004;41:147-8.

Sharma P, Chander B, Agrawal A, Kumar S. Primary prophylaxis of overt hepatic encephalopathy in patients with cirrhosis: an open labeled randomized controlled trial of lactulose versus no lactulose. J Gastroenterol Hepatol. 2012;27:1329-35.

Kappus M, Bajaj J. Covert hepatic encephalopathy: not as

minimal as you might think. Clin Gastroenterol Hepatol.

;10:1208-19.

Publicado

2017-02-15

Cómo citar

Gómez, C., & Restrepo, J. C. (2017). Encefalopatía hepática mínima. Revista Colombiana De Gastroenterología, 31(2), 154–160. https://doi.org/10.22516/25007440.84

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