Aproximación para establecer y evaluar la relevancia clínica de las interacciones medicamentosas en el tratamiento de pacientes infectados con virus de hepatitis C, revisión estructurada (actualización 2015 – 2017)

  • Daniel Esteban Pino Marín Universidad de Antioquia
  • Pedro Amariles Universidad de Antioquia
  • Jaime Alberto Peláez Alvárez Hospital infantil los Angeles
  • Gloria Priscilla Alvárez Osorio
  • Juliana González Ceballos
Palabras clave: Interacciones medicamentosas, Hepatitis C, Antivirales

Resumen

Objetivo: establecer y evaluar la relevancia clínica de las interacciones medicamentosas en el tratamiento de pacientes con hepatitis C. Método: se realizó una búsqueda en PubMed/MedLine de artículos publicados en inglés y en español, desde el 1 de enero de 2015 hasta el 30 de marzo de 2017, utilizando los términos Mesh: Hepatitis C AND drug interactions OR herb-drug interactions OR food-drug interactions, de estudios realizados en humanos. La relevancia clínica de las interacciones medicamentosas se estableció y evaluó con base en la probabilidad de ocurrencia y la gravedad de la interacción. Resultados: se identificaron 184 artículos, de los cuales 92 se seleccionaron por el título y resumen para revisión completa, a 2 de ellos no fue posible acceder al texto completo. De estos, 57 aportaban interacciones, lo que permitió identificar 155 parejas de interacciones medicamentosas, de las cuales 154 (99,4 %) fueron farmacocinéticas y 1 (0,6 %) farmacodinámica. Por su parte, de las 155 parejas, 34 (21,9 %) se valoraron de nivel 1; 73 (47,1 %) de nivel 2; 48 (31,0 %) de nivel 3; y 0 (0,0 %) de nivel 4. Además, se identificaron 29 parejas agrupadas como interacciones con evidencia de ausencia de relevancia clínica. Conclusiones: más de 99 % de las interacciones medicamentosas de relevancia clínica son farmacocinéticas, asociadas con cambios en el metabolismo y el transporte de fármacos; el simeprevir y la terapia 3D (Paritaprevir/Ritonavir+ Ombitasvir+Dasabuvir) fueron los medicamentos con mayor número de interacciones.

Biografía del autor/a

Daniel Esteban Pino Marín, Universidad de Antioquia
Químico farmacéutico, depto de farmacia de la Universidad de Antioquia UdeA, Medellín. Grupo de promoción y prevención farmacéutica (P&PF) de la Universidad de Antioquia
Pedro Amariles, Universidad de Antioquia
Químico farmacéutico, depto de farmacia de la Universidad de Antioquia UdeA, Medellín. Grupo de promoción y prevención farmacéutica (P&PF) de la Universidad de Antioquia
Jaime Alberto Peláez Alvárez, Hospital infantil los Angeles
Químico farmacéutico, depto de farmacia de la Universidad de Antioquia UdeA, Medellín. Grupo de promoción y prevención farmacéutica (P&PF) de la Universidad de Antioquia
Gloria Priscilla Alvárez Osorio
Químico farmacéutico, depto de farmacia de la Universidad de Antioquia UdeA, Medellín. Grupo de promoción y prevención farmacéutica (P&PF) de la Universidad de Antioquia
Juliana González Ceballos
Químico farmacéutico, depto de farmacia de la Universidad de Antioquia UdeA, Medellín. Grupo de promoción y prevención farmacéutica (P&PF) de la Universidad de Antioquia

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Publicado
2019-07-02
Sección
Revisión de tema