Zenker’s diverticulum: endoscopic treatment with or without diverticulotome

Authors

DOI:

https://doi.org/10.22516/25007440.504

Keywords:

Dysphagia, Zenker, endoscopic diverticulotomy, diverticulotome, complications

Abstract

Zenker’s diverticulum is defined as a diverticulum located in the posterior esophageal wall, just above the
cricopharyngeal muscle. Most patients experience symptoms in this area after the age of 60. In the past, the standard treatment was surgical diverticulotomy, but endoscopic treatment was introduced over 20 years ago. For more than 15 years, overtubes are introduced to facilitate the procedure, but their use is not been widely established in our country. Therefore, this study aims to evaluate whether endoscopic diverticulotomy with the use of this device is easier (faster) than the standard method.

Materials and methods: A prospective study was conducted to establish which of the two endoscopic methods to treat Zenker’s diverticulum (ZD) made the septum incision time shorter. The time count was done using video recording and started when the probe —standard method (SM)— or the overtube (MD) were placed, as this is the exact moment when septum cutting begins. The count stopped when the cut was finalized.

Results: A total of 20 patients were treated from January 2015 to December 2018. Zenker’s diverticulum diagnosis was achieved by endoscopy and esophagogram to classify the size of the tumor. The average age of the patients was 61 years (46-85). Ten patients were assigned to each group. Symptoms resolved in 7 patients of the SM group, compared to 9 in the MD group. The three patients who did not respond to the treatment were classified as stage II in the functional outcome swallowing scale at 18 months of follow-up. The average time of the procedure was 32 (25-45) minutes in the SM group and 12 (7-15) minutes in the MD group (p <0.001).

Conclusions: ZD myotomy with flexible endoscopy using an overtube has potential benefits in terms of shorter operative times, shorter post-operative stays, and an earlier reintroduction of food. From a technical point of view, this method allows for better exposure of the septum, which facilitates cutting. However, more extensive studies are needed to confirm these results.

Downloads

Download data is not yet available.

Author Biographies

Martin Alonso Gómez Zuleta, Universidad Nacional de Colombia

Médico Internista y Gastroenterólogo. Unidad de Gastroenterología y Ecoendoscopia (UGEC). Hospital Universitario Nacional de Colombia. Profesor asociado de Medicina, Universidad Nacional de Colombia. Bogotá.

Oscar Fernando Ruíz, Hospital Universitario Nacional de Colombia

Médico internista y gastroenterólogo. Unidad de gastroenterología y endoscopia, UGEC. Hospital Universitario Nacional de Colombia.

Hernando Marulanda Fernández, Hospital Universitario Nacional de Colombia

Médico internista y gastroenterólogo, Universidad Nacional de Colombia. Hospital Universitario Nacional de Colombia.

References

Tabola R, Lewandowski A, Cirocchi R, Augoff K, Kozminska U, Grabowski K. Zenker diverticulum: Experience in surgical treatment of large diverticula. Medicine (Baltimore). 2018;97:e0557.

https://doi.org/10.1097/MD.0000000000010557

Visser LJ, Hardillo JA, Monserez DA, Wieringa MH, Baatenburg de Jong RJ. Zenker's diverticulum: Rotterdam experience. Eur Arch Otorhinolaryngol 2016;273: 2755-63.

https://doi.org/10.1007/s00405-015-3825-0

Al-Kadi A, Maghrabi A, Thomson D, MGillman L, Dhalla S. Endoscopic Treatment of Zenker. Diverticulum: Results of a 7-Year Experience. J Am Coll Surg 2010; 211: 239-243.

https://doi.org/10.1016/j.jamcollsurg.2010.04.011

Gómez Z MA, Ardila SF, Arbeláez V. Experiencia en el manejo del divertículo de Zenker: Una serie de 18 casos. Rev Col Gastroenterol. 2011; 26: 100-105.

Ishaq S, Sultan H, Siau K, Kuwai T, Mulder CJ, Neumann H. New and emerging techniques for endoscopic treatment of Zenker's diverticulum: State-of-the-art review. Dig Endosc. 2018;30(4):449-460.

https://doi.org/10.1111/den.13035

Law R, Katzka DA, Baron TH. Zenker's Diverticulum. Clinical Gastroenterology and Hepatology. 2014;12(11): 1773 - 1782.

https://doi.org/10.1016/j.cgh.2013.09.016

Ciuc D, Birlă R, Panaitescu E, Tanţău M, Constantinoiu S. Zenker Diverticulum Treatment: Endoscopic or Surgical? Chirurgia (Bucur). 2018;113(2):234-243.

https://doi.org/10.21614/chirurgia.113.2.234

Jones D, Aloraini A, Gowing S, Cools-Lartigue J, Leimanis M, Tabah R, Ferri L. Evolving Management of Zenker's Diverticulum in the Endoscopic Era: A North American Experience. World J Surg. 2016;40(6):1390-6.

https://doi.org/10.1007/s00268-016-3442-0

Prisman E, Genden EM. Zenker diverticulum. Otolaryngol Clin North Am. 2013;46(6):1101-11.)

https://doi.org/10.1016/j.otc.2013.08.011

Henry MA, Lerco MM, Tagliarini JV, Castilho EC, Novaes FT, Lamonica VC. Pharyngoesophageal diverticulum: evaluation of treatment results. Rev Col Bras Cir. 2013;40(2):104-9.

https://doi.org/10.1590/S0100-69912013000200004

Aghajanzadeh M, Yousefi-Mashhoor M, Delshad MAE, et al. Zenker's Diverticulum: Report Rare Presentation and Management of Six Cases. Gastroenterol Hepatol Open Access 2016, 4(6): 00124.

https://doi.org/10.15406/ghoa.2016.04.00124

Stewart, KE, Smith, DRK, Woolley, SL. Simultaneously occurring Zenker's diverticulum and Killian-Jamieson diverticulum: case report and literature review. The Journal of Laryngology & Otology. 2017;131(8), 661-666.

https://doi.org/10.1017/S0022215117001268

Dina I, Ginghina O, Toderescu C D, et al. Zenker's diverticulum and squamous esophageal cancer: a case report. Journal of Mind and Medical Sciences,2017;4(2), 193-197

https://doi.org/10.22543/7674.42.P193197

Mantsopoulos, K., Psychogios, G., Karatzanis, A. Et al. Clinical relevance and prognostic value of radiographic findings in Zenker's diverticulum. European Archives of Oto-Rhino-Laryngology, 2013; 271(3), 583-588. Miller FR, Taylor C. Zenker's Diverticulum: Endoscopic Surgical Management Options. Clin Surg. 2017; 2: 1422.

https://doi.org/10.1007/s00405-013-2562-5

Aiolfi A, Scolari F, Saino G, et al. Current status of minimally invasive endoscopic management for Zenker diverticulum. World J Gastrointest Endosc 2015;7:87-93

https://doi.org/10.4253/wjge.v7.i2.87

Albers DV, Kondo A, Bernardo WM, et al. Endoscopic versus surgical approach in the treatment of Zenker's diverticulum: systematic review and meta-analysis. Endosc Int Open. 2016; 4(6): E678-E686

https://doi.org/10.1055/s-0042-106203

Bloom J D, Bleier B S, Mirza N. et al. Factors predicting endoscopic exposure of Zenker's diverticulum. Ann Otol Rhinol Laryngol. 2010;119:736-741.

https://doi.org/10.1177/000348941011901116

Saetti R, Silvestrini M, Peracchia A. et al. Endoscopic stapler-assisted Zenker's diverticulotomy: which is the best operative facility? Head Neck. 2006;28:1084-1089

https://doi.org/10.1002/hed.20431

Salassa, J. A Functional Outcome Swallowing Scale for Staging Oropharyngeal Dysphagia. Digestive Diseases, 17(4), 230-234.

https://doi.org/10.1159/000016941

Bergeron JL, Long JL, Chhetri DK. Dysphagia Characteristics in Zenker's Diverticulum. Otolaryngol Head Neck Surg. 2013; 148(2): 223-228

https://doi.org/10.1177/0194599812465726

Mantsopoulos, K., Psychogios, G., Karatzanis, A. Et al. Clinical relevance and prognostic value of radiographic findings in Zenker's diverticulum. European Archives of Oto-Rhino-Laryngology, 2013; 271(3), 583-588.

https://doi.org/10.1007/s00405-013-2562-5

Ferreira LE, Simmons DT, Baron TH. Zenker's diverticula: pathophysiology, clinical presentation, and flexible endoscopic management. Dis Esophagus 2008;21:1-8.

https://doi.org/10.1111/j.1442-2050.2007.00795.x

Bizzotto, A., Iacopini, F., Landi, R., Costamagna, G. Zenker's diverticulum: exploring treatment options. Acta Otorhinolaryngologica Italica, 2013.33(4), 219.

Naprawa, Grzegorz, and Joanna Białkowska. "Foreign body in a Zenker's diverticulum (looking for the lost dentures)." Przeglad gastroenterologiczny 2014;9.4: 254.

https://doi.org/10.5114/pg.2014.45109

Mantsopoulos K, Psychogios G, Karatzanis A, et al. Clinical relevance and prognostic value of radiographic findings in Zenker's diverticulum. Eur Arch Otorhinolaryngol 2014;271: 583-588.

https://doi.org/10.1007/s00405-013-2562-5

Babür, T. Iatrogenic Zenker's diverticulum perforation: A conservatively treated case. Turkish Journal of Surgery/Ulusal cerrahi dergisi, 2014;30(4), 234.

https://doi.org/10.5152/UCD.2013.24

Rizzetto, C., Zaninotto, G., Costantini, M., Bottin, R., Finotti, E., Zanatta, et al. Zenker's diverticula: feasibility of a tailored approach based on diverticulum size. Journal of Gastrointestinal Surgery, 2008;12(12), 2057-2065.

https://doi.org/10.1007/s11605-008-0684-7

Sakai, P. Endoscopic myotomy of Zenker's diverticulum: lessons from 3 decades of experience. Gastrointestinal endoscopy, 2016;83(4), 774-775.

https://doi.org/10.1016/j.gie.2015.10.031

Verdonck J, Morton RP. Systematic review on treatment of Zenker's diverticulum. Eur Arch Otorhinolaryngol 2015; 272: 3095-3107.

https://doi.org/10.1007/s00405-014-3267-0

Battaglia G, Antonello A, Realdon S, et al. Flexible endoscopic treat- ment for Zenker's diverticulum with the SB knife. Preliminary results from a single-center experience. Dig Endosc 2015;27:728-33.

https://doi.org/10.1111/den.12490

Nielsen HU, Trolle W, Rubek N, et al. New technique using LigaSure for endoscopic mucomyotomy of Zenker's diverticulum: diverticulotomy made easier. Laryngoscope 2014;124:2039-42.

https://doi.org/10.1002/lary.24558

Ishaq S, Hassan C, Antonello A, Tanner K, Bellisario C, Battaglia G, Anderloni A, Correale L, Sharma P, Baron

TH, Repici A. Flexible endoscopic treatment for Zenker’s diverticulum: a systematic review and meta-analysis.

Gastrointest Endosc. 2016;83(6):1076-1089.e5.

https://doi.org/10.1016/j.gie.2016.01.039

Wilmsen J, Baumbach R, Stüker D, Weingart V, Neser F, Gölder SK, Pfundstein C, Nötzel EC, Rösch T, Faiss S. New flexible endoscopic controlled stapler technique for the treatment of Zenker’s diverticulum: A case series. World J Gastroenterol. 2017;23(17):3084-3091.

https://doi.org/10.3748/wjg.v23.i17.3084

Yuan Y, Zhao YF, Hu Y, Chen LQ. Surgical treatment of Zenker’s diverticulum. Dig Surg. 2013;30(3):207-18.

https://doi.org/10.1159/000351433

Fan HS, Stavert B, Chan DL, Talbot ML. Management of Zenker’s diverticulum using flexible endoscopy. VideoGIE. 2019;4(2):87-90.

https://doi.org/10.1016/j.vgie.2018.12.007

Pescarus R, Shlomovitz E, Sharata AM, Cassera MA, Reavis KM, Dunst CM, Swanström LL. Trans-oral cricomyotomy using a flexible endoscope: technique and clinical outcomes. Surg Endosc. 2016;30(5):1784-9.

https://doi.org/10.1007/s00464-015-4445-x

Yang J, Novak S, Ujiki M, Hernández Ó, Desai P, Benias P, Lee D, Chang K, Brieau B, Barret M, Kumta N, Zeng

X, Hu B, Delis K, Khashab MA. An international study on the use of peroral endoscopic myotomy in the management of Zenker›s diverticulum. Gastrointest Endosc. 2020;91(1):163-168.

https://doi.org/10.1016/j.gie.2019.04.249

Ishaq S, Kuwai T, Siau K, Mulder CJ, Neumann H. Is Z-POEM for Zenker›s the same as POEM for achalasia?

Or we are barking up the wrong tree? Gastrointest Endosc. 2020;91(1):204-205.

https://doi.org/10.1016/j.gie.2019.07.028

Ko FC. Preoperative Frailty Evaluation: A Promising Riskstratification Tool in Older Adults Undergoing General Surgery. Clin Ther. 2019;41(3):387-399.

https://doi.org/10.1016/j.clinthera.2019.01.014

Shinall MC Jr, Arya S, Youk A, Varley P, Shah R, Massarweh NN, Shireman PK, Johanning JM, Brown AJ,

Christie NA, Crist L, Curtin CM, Drolet BC, Dhupar R, Griffin J, Ibinson JW, Johnson JT, Kinney S, LaGrange

C, Langerman A, Loyd GE, Mady LJ, Mott MP, Patri M, Siebler JC, Stimson CJ, Thorell WE, Vincent SA,

Hall DE. Association of Preoperative Patient Frailty and Operative Stress With Postoperative Mortality. JAMA Surg. 2019;155(1):e194620.

https://doi.org/10.1001/jamasurg.2019.4620

Figura 3. Divertículo de Zenker con el diverticulotomo separando claramente el tabique, el cual se ha cortado con el bisturí de punta

Published

2020-12-21

How to Cite

Gómez Zuleta, M. A., Ruíz, O. F., & Marulanda Fernández, H. (2020). Zenker’s diverticulum: endoscopic treatment with or without diverticulotome. Revista Colombiana De Gastroenterología, 35(4), 421–429. https://doi.org/10.22516/25007440.504

Issue

Section

Originals articles

Altmetric

Article metrics
Abstract views
Galley vies
PDF Views
HTML views
Other views
QR Code

Some similar items: